They also performed tests in pig lungs and trachea, showing that they could rapidly repair damage to those organs. To explore possible applications for the new double-sided tape, the researchers tested it in a few different types of pig tissue, including skin, small intestine, stomach, and liver. This type of adhesive could have a major impact on surgeons’ ability to seal incisions and heal wounds, Yuk says. “Combining two innovative concepts, the research team succeeded in adhering quickly and effectively to the wet and soft surface of a tissue, and in maintaining good adhesion and mechanical properties for several days without causing too much inflammatory response,” says Costantino Creton, a research director at ESPCI Paris, who was not involved in the research. Gelatin tends to break down within a few days or weeks in the human body, while chitosan can last longer (a month or even up to a year). Depending on the application that the tape is being used for, the researchers can control how fast it breaks down inside the body by varying the ingredients that go into it. These polymers allow the adhesive to hold its shape for long periods of time. To make their tape tough enough to last inside the body, the researchers incorporated either gelatin or chitosan (a hard polysaccharide found in insect shells). These hydrogen bonds and other weak interactions temporarily hold the tape and tissues in place while chemical groups called NHS esters, which the researchers embedded in the polyacrylic acid, form much stronger bonds, called covalent bonds, with proteins in the tissue. As soon as the tape is applied, it sucks up water, allowing the polyacrylic acid to quickly form weak hydrogen bonds with both tissues. For water absorption, they used polyacrylic acid, a very absorbent material that is used in diapers. To mimic this with an engineered adhesive, the researchers designed a material that first absorbs water from wet tissues and then rapidly binds two tissues together.
#Double sided medical tape Patch
This spider glue includes charged polysaccharides that can absorb water from the surface of an insect almost instantaneously, clearing off a small dry patch that the glue can adhere to. To create a double-sided tape that could rapidly join two wet surfaces together, the team drew inspiration from the natural world - specifically, the sticky material that spiders use to capture their prey in wet conditions. Zhao’s group had previously developed other novel adhesives, including a hydrogel superglue that provides tougher adhesion than the sticky materials that occur in nature, such as those that mussels and barnacles use to cling to ships and rocks.
The MIT team wanted to come up with something that would work much faster. Existing tissue glues diffuse adhesive molecules through the water between two tissue surfaces to bind them together, but this process can take several minutes or even longer. Other authors are MIT graduate student Xinyu Mao, MIT assistant professor of mechanical engineering Ellen Roche, Mayo Clinic critical care physician Christoph Nabzdyk, and Brigham and Women’s Hospital pathologist Robert Padera.įorming a tight seal between tissues is considered to be very difficult because water on the surface of the tissues interferes with adhesion. Graduate students Hyunwoo Yuk and Claudia Varela are the lead authors of the study, which appears today in Nature. In addition, it works much faster than tissue glues, which usually take several minutes to bind tightly and can drip onto other parts of the body. The double-sided tape can also be used to attach implantable medical devices to tissues, including the heart, the researchers showed. We are proposing a fundamentally different approach to sealing tissue,” says Xuanhe Zhao, an associate professor of mechanical engineering and of civil and environmental engineering at MIT and the senior author of the study. “There are over 230 million major surgeries all around the world per year, and many of them require sutures to close the wound, which can actually cause stress on the tissues and can cause infections, pain, and scars. They hope that this tape could eventually be used in place of surgical sutures, which don’t work well in all tissues and can cause complications in some patients. In tests in rats and pig tissues, the researchers showed that their new tape can tightly bind tissues such as the lungs and intestines within just five seconds.
Inspired by a sticky substance that spiders use to catch their prey, MIT engineers have designed a double-sided tape that can rapidly seal tissues together.
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